Human Gastrin-71 Protein, Fc tag

Human Gastrin-71 Protein, Fc tag (GAN-H5253) is expressed from human 293 cells (HEK293). It contains AA Ser 22 - Phe 92 (Accession # P01350-1).

Product Specifications

Background

Gastrin is a peptide hormone that stimulates secretion of gastric acid (HCl) by the parietal cells of the stomach and aids in gastric motility. It is released by G cells in the pyloric antrum of the stomach, duodenum, and the pancreas. Gastrin binds to cholecystokinin B receptors to stimulate the release of histamines in enterochromaffin-like cells, and it induces the insertion of K+/H+ ATPase pumps into the apical membrane of parietal cells (which in turn increases H+ release into the stomach cavity). Its release is stimulated by peptides in the lumen of the stomach.

Specifications

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 34.5 kDa. The protein migrates as 33-35 kDa and 40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Expression Region

Ser 22 - Phe 92

Host

HEK 293

Target

Gastrin-71

Conjugation

Unconjugated

Tag

C-Fc

Source

Human

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.