Anti-BAFF (CT) Antibody

Rabbit Polyclonal Antibody specific to BAFF (CT)

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

B lymphocyte stimulator, BLyS, B-cell-activating factor, BAFF, Dendritic cell-derived TNF-like molecule, TNF- and APOL-related leukocyte expressed ligand 1, TALL-1, CD antigen CD257 [Cleaved into: Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form]

Gene Name

TNFSF13B

Gene ID

10673

NCBI Gene ID

<a href="https://www.ncbi.nlm.nih.gov/gene/?term=TNFSF13B">TNFSF13B</a>

UniProt

Q9Y275

Accession Number

NP_006564

Cellular Locus

Cell membrane; Single-pass type II membrane protein.; [Tumor necrosis factor ligand superfamily member 13b, soluble form]: Secreted.

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Peptide corresponding to aa 254-269 at the C-terminus of human BAFF.

Target Antigen

Tumor necrosis factor ligand superfamily member 13B

Target

BAFF (CT)

Clonality

Polyclonal

Isotype

IgG

Type

Antibody

Applications

ELISA, WB, ICC, IF, IHC

Field of Research

Apoptosis

Purification Method

Purified by peptide immuno-affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium which is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. {PubMed:10973284}.; Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. {PubMed:10973284}.

Additionnal Information

Immunoblotting: use at 1ug/mL. Immunocytochemistry: use at 1ug/mL. These are recommended concentrations. Enduser should determine optimal concentration for their application. Positive control: Whole cell lysate from HL60 cells.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.

Specificity

This antibody recognizes human, mouse, and rat BAFF (approx. 38kDa).

Formulation

PBS, pH 7.4.

Buffer pH

pH 7.4

Target Background

A novel member of the TNF superfamily was recently identified and designated BAFF (B Cell Activating Factor of the TNF Family) or BlyS (B Lymphocyte Stimulator), TALL-1 (TNF- and ApoL-Related Leukocyte-Expressed Ligand), and THANK (TNF Homologue that Activates Apoptosis, NF- B and c-jun N-terminal Kinase). BAFF is designated a B cell stimulator since it induces B cell proliferation and immunoglobulin secretion. BAFF and its receptors are involved in the development of systemic lupus erythematosus and other B cell-associated autoimmune diseases.