SARS-CoV-2 ORF8 Protein, His Tag (MALS verified)
The viral protein encoded by open reading frame 8 (ORF8) of SARS-CoV-2, which shares the least homology with SARS-CoV among all viral proteins, directly interacts with MHC-Ι molecules and mediates their down-regulation. In ORF8-expressing cells, MHC-Ι molecules are selectively targeted for lysosomal degradation via autophagy. Thus, SARS-CoV-2–infected cells are much less sensitive to lysis by cytotoxic T lymphocytes.
Product Specifications
Background
Specifications
Accession Number
P0DTC8-1
Expression Region
Phe 16 - Ile 121
Host
HEK293
Target
ORF8
Conjugation
Unconjugated
Tag
C-10xHis
Source
SARS-CoV-2
Stability
Endotoxin
1.0 EU per μg
Purity
90%
Format
Powder
Buffer
PBS, pH7.4
Additives
Trehalose
Molecular Weight
14.3 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
100ug*1
Host or Source
HEK293
Species
SARS-CoV-2
Protein ID
P0DTC8-1
Preservative
Trehalose
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