FITC-Labeled Human IL-15 R alpha / CD215 Protein, Fc Tag (MALS verified)
FITC-Labeled Human IL-15 R alpha, Fc Tag (ILA-HF255) is expressed from human 293 cells (HEK293) . It contains AA Ile 31-Thr 205 (Accession # Q13261-1) .
Product Specifications
Background
IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG. IL-15RA, also known as CD215, IL-15 R alpha, is a widely expressed 60 kDa transmembrane glycoprotein. High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. An interleukin (IL) -15 superagonist/IL-15 receptor α fusion complex (IL-15SA/IL-15RA; ALT-803) activates the IL-15 receptor on CD8 T cells and NK cells, and has shown significant anti-tumor. Signal transduction involves SYK. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures.
Specifications
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 44.8 kDa. The protein migrates as 65-80 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Accession Number
Q13261-1
Expression Region
Ile 31-Thr 205
Host
HEK293
Target
IL-15 R alpha
Conjugation
FITC Labeled
Tag
C-Fc
Source
Human
Stability
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Endotoxin
1.0 EU per μg
Purity
95%
Bioactivity
Immobilized Human IL-15, His Tag (Cat. No. IL5-H52H8) at 2 μg/mL (100 μL/well) can bind FITC-Labeled Human IL-15 R alpha, Fc Tag (Cat. No. ILA-HF255) with a linear range of 0.078-5 μg/mL (QC tested).
Format
Powder
Buffer
PBS, 0.2 M Arginine, pH7.4
Additives
Trehalose
Molecular Weight
44.8 kDa
Shipping Conditions
RT
Storage Conditions
-20°C, aviod light
Package Size
25ug*1
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/ILA-HF255.pdf
Species
Human
Curated Selection
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