Human USAG-1 Protein, Fc Tag

USAG1 (uterine sensitization associated gene 1), also known asSOSTDC1 (sclerostin domain–containing 1), Ectodin, is a secreted protein with a glycosylated N-terminus that contains a C-terminal cysteine knot domain. This C-terminal cysteine knot domain is present in numerous growth factors, including TGFβ, NGF, PDGF, vWF, NDP, and mucin-2, and involved in dimerization, receptor binding, and signal transduction. SOSTDC1 negatively regulates BMP signaling during cellular proliferation, differentiation, and apoptosis in several biological processes (such as dentary morphogenesis, embryo implantation in the endo-metrium, and healing of bone fractures) [8]. In addition, SOSTDC1 might also involve cancer development processes through the regulation of the Wnt pathway.

Product Specifications

Background

Specifications

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 47.2 kDa. The protein migrates as 33 kDa, 38 kDa, 55-65 kDa and 100 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Accession Number

Q6X4U4-1

Expression Region

Phe 24 - Ser 206

Host

HEK293

Target

USAG-1

Conjugation

Unconjugated

Tag

C-Fc

Source

Human

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.