Biotinylated Cynomolgus TSLP Protein, His, Avitag™ (MALS verified)

Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine involved in the pathology of inflammatory skin diseases, and is widely expressed by epithelial cells. Human TSLP cDNA encodes a 159 amino acid (aa) residue precursor protein with a 28 aa signal sequence (4, 5) . Human TSLP has been shown to developing nondeletional central tolerance, amplifying epithelium-induced class switching, inducing atopic diseases and maintaining intestinal noninflammatory environment. Among diverse cells responding to Human TSLP, CD11c+ dendritic cells are the most obviously characterized target cells.

Product Specifications

Background

Specifications

This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™) . The protein has a calculated MW of 18.8 kDa. The protein migrates as 12 kDa under reducing (R) condition (SDS-PAGE) .

Accession Number

A0A7N9CAT7-1

Expression Region

Tyr 29 - Gln 159

Host

HEK293

Target

TSLP

Conjugation

Biotin-labeled

Tag

C-10xHis & C-Avi

Source

Cynomolgus

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin

1.0 EU per μg

Purity

90%

Bioactivity

Immobilized Human TSLP R, Fc Tag (Cat. No. TSR-H525a) at 5 μg/mL (100 μL/well) can bind Biotinylated Cynomolgus TSLP, His,Avitag (Cat. No. TSP-C82E3) with a linear range of 0.1-2 ng/mL (QC tested).