FXIIa-IN-4

FXIIa-IN-4 (compound 22) is a potent, selective human FXIIa inhibitor with the IC50 of 0.032 μM, 0.30 μM, > 50 μM for FXIIa, thrombin and FXIa, respectively. FXIIa-IN-4 can be used for study of anticoagulant[1].

Product Specifications

UNSPSC

12352005

Target

Factor Xa; Thrombin

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/fxiia-in-4.html

Concentration

10mM

Purity

98.87

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=NN(C(C2=CC=C(F)C=C2)=O)C(N)=N1)OC

Molecular Formula

C11H9FN4O3

Molecular Weight

264.21

References & Citations

[1]Ma’Lik D. Woodland, et al. New Triazole-Based Potent Inhibitors of Human Factor XIIa as Anticoagulants. ACS Omega 2024, 9, 9, 10694–10708.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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