Human UCH-L1 Protein, His Tag
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1), a member of the peptidase C12 family, is also known as neuron cytoplasmic protein 9.5 (PGP 9.5) and ubiquitin thioesterase L1.About 30% of total UCHL1 is associated with membranes in brain. UCHL1 is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also, UCHL1 can bind to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer of UCHL1 may have ATP-independent ubiquitin ligase activity. Furthermore, the mutations of UCHL1 gene can result in parkinson disease 5.
Product Specifications
Background
Specifications
Accession Number
NP_004172
Expression Region
Gln 2 - Ala 223
Host
E. coli
Target
UCH-L1
Conjugation
Unconjugated
Tag
N-6xHis
Source
Human
Stability
Endotoxin
1.0 EU per μg
Purity
95%
Format
Powder
Buffer
50 mM Tris, 150 mM Nacl, pH8.0
Additives
Trehalose
Molecular Weight
25.7 kDa
Additionnal Information
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Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
500ug*2
Host or Source
E. coli
Species
Human
Protein ID
NP_004172
Preservative
Trehalose
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