Cynomolgus TRAIL R2 / DR5 / TNFRSF10B Protein, His Tag (MALS verified)
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is also known as TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2), Death receptor 5 (DR5), CD262, KILLER, is a member of the TNF-receptor superfamily, and contains an intracellular death domain. TNFRSF10B / DR-5 is widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines. TRAILR2 / CD262 / DR5 is the receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD (a death domain containing adaptor protein) of TRAIL-R2 / TNFRSF10B recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. CD262 / DR5 Promotes the activation of NF-kappa-B. DR5 is essential for ER stress-induced apoptosis and is regulated by p53/TP53.
Product Specifications
Background
Specifications
Accession Number
A0A2K5TXK0-1
Expression Region
Ile 58 - Ser 212
Host
HEK293
Target
TRAIL R2
Conjugation
Unconjugated
Tag
C-10xHis
Source
Cynomolgus
Stability
Endotoxin
1.0 EU per μg
Purity
90%
Bioactivity
Format
Powder
Buffer
PBS, pH7.4
Additives
Trehalose
Molecular Weight
19.1 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
100ug*1
Host or Source
HEK293
Species
Cynomolgus
Protein ID
A0A2K5TXK0-1
Preservative
Trehalose
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