Human TOP2A / TOP2 Protein, Tag Free
DNA topoisomerase 2-alpha (TOP2A) is also known as DNA topoisomerase II, alpha isozyme and TOP2. It is a topoisomerase which control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation. Also it is the targets of anti-cancer drugs that cause treatment-related leukemias with balanced translocations.
Product Specifications
Background
Specifications
This protein carries no "tag". The protein has a calculated MW of 13.0 kDa. The protein migrates as 20 kDa under reducing (R) condition (SDS-PAGE) .
Accession Number
P11388-1
Expression Region
Ser 1354 - Ser 1473
Host
E. coli
Target
TOP2A
Conjugation
Unconjugated
Tag
Native
Source
Human
Stability
The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.
Endotoxin
1.0 EU per μg
Purity
90%
Format
Liquid
Buffer
50 mM Tris, 0.5 M KCl, pH8.0
Additives
Glycerol
Molecular Weight
13.0 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
Dry ice
Storage Conditions
-70°C
Package Size
20ug*1
Host or Source
E. coli
Species
Human
Protein ID
P11388-1
Preservative
Glycerol
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