Human Osteoprotegerin / TNFRSF11B Protein, Fc Tag
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) is also known as Osteoclastogenesis inhibitory factor (OCIF), Osteoprotegerin (OPG) . TNFRSF11B is a secreted homodimer protein, which can interact with TNFSF10 and TNFSF11. TNFRSF11B acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TNFRSF11B inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
Product Specifications
Background
Specifications
Accession Number
NP_002537
Expression Region
Glu 22 - Leu 401
Host
HEK293
Target
Osteoprotegerin
Conjugation
Unconjugated
Tag
C-Fc
Source
Human
Stability
Endotoxin
1.0 EU per μg
Purity
92%
Bioactivity
Format
Powder
Buffer
50 mM Tris, 100 mM Glycine, pH7.5
Additives
Trehalose
Molecular Weight
70.2 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
1mg*1
Host or Source
HEK293
Species
Human
Protein ID
NP_002537
Preservative
Trehalose
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