Human PLAU / uPA Protein, His Tag
Urokinase - type plasminogen activator is also known as PLAU and UPA, a serine protease with an extremely limited substrate specificity, cleaving the sequence Cys – Pro – Gly - Arg560 - Val561 – Val – Gly – Gly – Cys in plasminogen to form plasmin. uPA is a potent marker of invasion and metastasis in a variety of human cancers associated with breast, stomach, colon, bladder, ovary, brain and endometrium.uPA and its receptor (uPAR) have been implicated in a broad spectrum of pathophysiological processes, including fibrinolysis, proteolysis, inflammation, atherogenesis and plaque destabilization, all of which are involved in the pathogenesis of MI (myocardial infarction) .
Product Specifications
Background
Specifications
Please note that the protein is not activated by protease digestion. In vitro activation is generally recommended for higher activity.
Accession Number
NP_002649.1
Expression Region
Ser 21 - Leu 431
Host
HEK293
Target
PLAU
Conjugation
Unconjugated
Tag
C-6xHis
Source
Human
Stability
Endotoxin
1.0 EU per μg
Purity
92%
Bioactivity
Format
Powder
Buffer
50 mM Sodium Acetate, 100 mM NaCl, pH5.0
Additives
Trehalose
Molecular Weight
47.2 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
250ug*4
Host or Source
HEK293
Species
Human
Protein ID
NP_002649.1
Preservative
Trehalose
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