Human LRP-6 (20-630) Protein, Mouse IgG2a Fc Tag
Human LRP-6 (20-630), Mouse IgG2a Fc Tag (LR6-H5253) is expressed from human 293 cells (HEK293) . It contains AA Ala 20 - Pro 630 (Accession # O75581-1) .
Product Specifications
Background
LRP6 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP5. Low-density lipoprotein receptor-related protein 6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin.
Specifications
This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 95.8 kDa. The protein migrates as 55 kDa and 110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Accession Number
O75581-1
Expression Region
Ala 20 - Pro 630
Host
HEK293
Target
LRP-6
Conjugation
Unconjugated
Tag
C-mFc (mIgG2a)
Source
Human
Stability
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Endotoxin
0.1 EU per μg
Purity
90%
Bioactivity
Immobilized Mouse Dkk-1, His Tag (Cat. No. DK1-M52H6) at 5 μg/mL (100 μL/well) can bind Human LRP-6 (20-630), Mouse IgG2a Fc Tag (Cat. No. LR6-H5253) with a linear range of 10-78 ng/mL (QC tested).
Format
Powder
Buffer
Tris with Glycine, Arginine and NaCl, pH7.5
Additives
Trehalose
Molecular Weight
95.8 kDa
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
100ug*1
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/LR6-H5253.pdf
Species
Human
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