Human LRP-6 (20-630) Protein, Mouse IgG2a Fc Tag
LRP6 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP5. Low-density lipoprotein receptor-related protein 6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin.
Product Specifications
Background
Specifications
Accession Number
O75581-1
Expression Region
Ala 20 - Pro 630
Host
HEK293
Target
LRP-6
Conjugation
Unconjugated
Tag
C-mFc (mIgG2a)
Source
Human
Stability
Endotoxin
0.1 EU per μg
Purity
90%
Bioactivity
Format
Powder
Buffer
Tris with Glycine, Arginine and NaCl, pH7.5
Additives
Trehalose
Molecular Weight
95.8 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
100ug*1
Host or Source
HEK293
Species
Human
Protein ID
O75581-1
Preservative
Trehalose
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