Human Integrin alpha 10 beta 1 (ITGA10&ITGB1) Heterodimer Protein, His Tag&Tag Free
Human integrin alpha (10) I domain as a recombinant protein to reveal its ligand binding specificity. In general, alpha (10) I did recognize collagen types I-VI and laminin-1 in a Mg (2+) -dependent manner, whereas its binding to tenascin was only slightly better than to albumin. Alpha 10 beta 1 is a known collagen-binding I domain integrin, in addition to α1β1, α2β1 and α11β1. GROGER found in the N-terminal domain of collagens I and III, is only weakly recognised by α10β1, an important collagen receptor on chondrocytes, contrasting with the other collagen-binding integrins.
Product Specifications
Background
Specifications
Accession Number
O75578-1 (ITGA10) & P05556-1 (ITGB1)
Expression Region
Phe 23 - Ser 1122 (ITGA10) & Gln 21 - Asp 728 (ITGB1)
Host
HEK293
Target
Integrin alpha 10 beta 1
Conjugation
Unconjugated
Tag
C-10xHis | Native
Source
Human
Stability
Endotoxin
1.0 EU per μg
Purity
95%
Bioactivity
Format
Powder
Buffer
50 mM Tris, 150 mM NaCl, pH7.5
Additives
Trehalose
Molecular Weight
126.6 kDa (ITGA10) & 83.7 kDa (ITGB1)
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
100ug*1
Host or Source
HEK293
Species
Human
Protein ID
O75578-1 (ITGA10) & P05556-1 (ITGB1)
Preservative
Trehalose
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