Human IL-11 R alpha Protein, Fc Tag (MALS verified)

Receptor for interleukin-11 (IL11) . The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells (Probable) . Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number.Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 64.3 kDa. The protein migrates as 70-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Immobilized Human IL-11, His Tag (Cat. No. IL1-H5243) at 5 μg/mL (100 μL/well) can bind Human IL-11 R alpha, Fc Tag (Cat. No. ILR-H5256) with a linear range of 1-10 ng/mL (QC tested).