Human IL-17 RA&IL-17 RC Heterodimer Protein, Fc Tag&Fc Tag (MALS verified)
Selected Variant
ILC-H5257-100ug
Size: 100 µg
Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC. Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation.
Product Specifications
Background
Specifications
Accession Number
Q96F46-1 (IL-17RA) & NP_703190.1 (IL-17RC)
Expression Region
Leu 33 - Trp 320 (IL-17RA) & Leu 21 - His 465 (IL-17RC)
Host
HEK293
Target
IL-17 RA & IL-17 RC
Conjugation
Unconjugated
Tag
C-Fc | C-Fc
Source
Human
Stability
Endotoxin
1.0 EU per μg
Purity
95%
Bioactivity
Format
Powder
Buffer
PBS, pH7.4
Additives
Trehalose
Molecular Weight
60.0 kDa (IL-17 RA) & 75.7 kDa (IL-17 RC)
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
100ug*1
Host or Source
HEK293
Species
Human
Protein ID
Q96F46-1 (IL-17RA) & NP_703190.1 (IL-17RC)
Preservative
Trehalose
Price
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