Human IL-31 RA Protein, His Tag (MALS & SPR verified)
Human IL-31 RA, His Tag (ILA-H52H7) is expressed from human 293 cells (HEK293) . It contains AA Ala 20 - Glu 519 (Accession # Q8NI17-1) .
Product Specifications
Background
Interleukin-31 receptor subunit alpha is a protein that in humans is encoded by the IL31RA gene, also known as IL-31 receptor subunit alpha, IL-31RA, GLM-R, Gp130-like receptor, CRL3, GPL. Oncostatin M receptor (OSMR) and IL31RA form the heterodimeric receptor through which IL31 signals. IL31RA is a strong activator of STAT3 and STAT5, whereas STAT1 is only marginally tyrosine-phosphorylated. dditionally, demonstrate Jak1 binding to GPL and its activation in heteromeric complexes with the OSMRbeta but also in a homomeric receptor complex.
Specifications
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 59.0 kDa. The protein migrates as 90-110 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Accession Number
Q8NI17-1
Expression Region
Ala 20 - Glu 519
Host
HEK293
Target
IL-31 RA
Conjugation
Unconjugated
Tag
C-10xHis
Source
Human
Stability
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Endotoxin
1.0 EU per μg
Purity
95%
Bioactivity
Immobilized Nemolizumab at 5 μg/mL (100 μL/well) can bind Human IL-31 RA, His Tag (Cat. No. ILA-H52H7) with a linear range of 1-39 ng/mL (Routinely tested).
Format
Powder
Buffer
PBS, pH7.4
Additives
Trehalose
Molecular Weight
59.0 kDa
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
100ug*1
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/ILA-H52H7.pdf
Species
Human
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