Human MUC-17 Protein, His Tag
Human MUC-17, His Tag (MU7-H52H3) is expressed from human 293 cells (HEK293) . It contains AA Arg 4131 - Leu 4390 (Accession # Q685J3-1) .
Product Specifications
Background
Membrane mucins have several functions in epithelial cells including cytoprotection, extravasation during metastases, maintenance of luminal structure, and signal transduction. MUC17, contains an extended, repetitive extracellular glycosylation domain and a carboxyl terminus with two EGF-like domains, a SEA module domain, a transmembrane domain, and a cytoplasmic domain with potential serine and tyrosine phosphorylation sites. Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization. Probably plays a role in maintaining homeostasis on mucosal surfaces.
Specifications
This protein carries a polyhistidine tag at the C-terminus. This protein was cleaved within the SEA domain between 4243 Gly and 4244 Ser, and was cleaved into N and C-terminal fragment with calculated MW of 12.6 kDa and 18.6 kDa respectively. The protein migrates as 20 kDa and 25-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Accession Number
Q685J3-1
Expression Region
Arg 4131 - Leu 4390
Host
HEK293
Target
MUC-17
Conjugation
Unconjugated
Tag
C-10xHis
Source
Human
Stability
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Endotoxin
1.0 EU per μg
Purity
90%
Format
Powder
Buffer
PBS, pH7.4
Additives
Trehalose
Molecular Weight
31.2 kDa
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
100ug*1
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/MU7-H52H3.pdf
Species
Human
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