Human ENPP-2 / Autotaxin Protein, His Tag (active enzyme)
Human ENPP-2, His Tag (EN2-H5241) is expressed from human 293 cells (HEK293) . It contains AA Asp 49 - Ile 863 (Accession # NP_001035181) .
Product Specifications
Background
Autotaxin also known as ectonucleotide pyrophosphatase / phosphodiesterase family member 2 (E-NPP 2 or ENPP2), Extracellular lysophospholipase D (LysoPLD), Autotaxin (ATX or ATX-X), which belongs to the nucleotide pyrophosphatase / phosphodiesterase family. ENPP2 contains two SMB (somatomedin-B) domains. ENPP2 hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. ENPP2 can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. ENPP2 stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein.
Specifications
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 94.5 kDa. The protein migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE) .
Accession Number
NP_001035181
Expression Region
Asp 49 - Ile 863
Host
HEK293
Target
ENPP-2
Conjugation
Unconjugated
Tag
N-6xHis
Source
Human
Stability
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Endotoxin
1.0 EU per μg
Purity
95%
Format
Powder
Buffer
50 mM Tris, 150 mM NaCl, pH7.5
Additives
Trehalose
Molecular Weight
94.5 kDa
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
50ug*1
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/EN2-H5241.pdf
Species
Human
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