PGN-9856
PGN-9856 is a selective and high affinity (pKi ≥ 8.3) ligand at EP2 receptor. PGN-9856 is a potetn and non-prostanoid EP2 receptor agonist (pEC50 ≥ 8.5) . PGN-9856 shows anti-inflammatory and anti-glaucoma activities[1].
Product Specifications
CAS Number
[863704-91-0]
Product Name Alternative
2-Octadecyl-1H-indole-5-carboxylic acid
UNSPSC
12352005
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pgn-9856.html
Purity
98.90
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(O)COC1=CC=CC(NC(C2=CC(C3=CC=CC(F)=C3)=CC=C2F)=O)=C1
Molecular Formula
C21H15F2NO4
Molecular Weight
383.34
References & Citations
[1]Coleman RA, et al. The affinity, intrinsic activity and selectivity of a structurally novel EP2 receptor agonist at human prostanoid receptors. Br J Pharmacol. 2019 Mar;176 (5) :687-698.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EP
Available Sizes
Curated Selection
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