PGN-9856

PGN-9856 is a selective and high affinity (pKi ≥ 8.3) ligand at EP2 receptor. PGN-9856 is a potetn and non-prostanoid EP2 receptor agonist (pEC50 ≥ 8.5) . PGN-9856 shows anti-inflammatory and anti-glaucoma activities[1].

Product Specifications

CAS Number

[863704-91-0]

Product Name Alternative

2-Octadecyl-1H-indole-5-carboxylic acid

UNSPSC

12352005

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pgn-9856.html

Purity

98.90

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(O)COC1=CC=CC(NC(C2=CC(C3=CC=CC(F)=C3)=CC=C2F)=O)=C1

Molecular Formula

C21H15F2NO4

Molecular Weight

383.34

References & Citations

[1]Coleman RA, et al. The affinity, intrinsic activity and selectivity of a structurally novel EP2 receptor agonist at human prostanoid receptors. Br J Pharmacol. 2019 Mar;176 (5) :687-698.