Cynomolgus LAG-3 / CD223 Protein, Fc Tag (MALS verified)
Cynomolgus LAG-3, Fc Tag (LA3-C5252) is expressed from human 293 cells (HEK293) . It contains AA Ala 18 - His 449 (Accession # XP_005570011.1) .
Product Specifications
Background
Lymphocyte activation gene 3 protein (LAG3) is also known as CD antigen CD223 and protein FDC, which belongs to immunoglobulin (Ig) superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. LAG3 /CD223 involved in lymphocyte activation. LAG3 /CD223 binds to HLA class-II antigens.
Specifications
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 73.0 kDa. The protein migrates as 85-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Accession Number
XP_005570011.1
Expression Region
Ala 18 - His 449
Host
HEK293
Target
LAG-3
Conjugation
Unconjugated
Tag
C-Fc
Source
Cynomolgus
Stability
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Endotoxin
1.0 EU per μg
Purity
90%
Bioactivity
Immobilized Cynomolgus LAG-3, Fc Tag (Cat. No. LA3-C5252) at 2 μg/mL (100 μL/well) can bind Anti-Human LAG3 MAb, Human IgG1 with a linear range of 8-31 ng/mL (QC tested).
Format
Powder
Buffer
Tris with Glycine, Arginine and NaCl, pH7.5
Additives
Trehalose
Molecular Weight
73.0 kDa
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
100ug*1
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/LA3-C5252.pdf
Species
Cynomolgus
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