Human Podoplanin / PDPN Protein, Fc Tag (MALS verified)

Podoplanin (PDPN) is a type I transmembrane mucin-like glycoprotein expressed in the lymphatic endothelium. It is overexpressed in several solid tumors, such as squamous cell carcinoma, malignant mesothelioma, Kaposi sarcoma, angiosarcoma, testicular seminoma, and brain tumors. PDPN expression is associated with malignant progression, epithelial–mesenchymal transition, and metastasis.

Product Specifications

Background

Specifications

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 37.6 kDa. The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Accession Number

Q86YL7-1

Expression Region

Ala 23 - Leu 131

Host

HEK293

Target

Podoplanin

Conjugation

Unconjugated

Tag

C-Fc

Source

Human

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin

0.1 EU per μg

Purity

90%

Bioactivity

Immobilized Human CLEC-2, His Tag (Cat. No. CL2-H5247) at 5 μg/mL (100 μL/well) can bind Human Podoplanin, Fc Tag (Cat. No. PON-H5254) with a linear range of 0.3-20 ng/mL (QC tested).