Human Tau-441 / 2N4R Protein, Tag Free, low endotoxin (MALS verified)

Tau is a microtubule-associated protein, which encodes by the MAPT gene that located on chromosome 17q21. Tau Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer's disease, frontotemporal dementia, and other tauopathies.

Product Specifications

Background

Specifications

This protein carries no "tag". The protein has a calculated MW of 45.8 kDa. The protein migrates as 30-53 kDa and 55-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) .

Accession Number

P10636-8

Expression Region

Met 1 - Leu 441

Host

E. coli

Target

Tau

Conjugation

Unconjugated

Tag

Native

Source

Human

Stability

The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.

Endotoxin

0.01 EU per μg

Purity

90%

Bioactivity

Immobilized Human Tau-441, Tag Free (Cat. No. TAU-H5117) at 1 μg/mL (100 μL/well) can bind Tau Monoclonal Antibody with a linear range of 0.4-6 ng/mL (QC tested).