Cynomolgus / Rhesus macaque BCMA / TNFRSF17 Protein, Fc Tag (MALS verified)

Cynomolgus / Rhesus macaque BCMA, Fc Tag (BCA-C5253) is expressed from human 293 cells (HEK293) . It contains AA Met 1 - Ala 53 (Accession # A0A2K5UD97-1) . In the region Met 1 - Ala 53, the AA sequence of Cynomolgus and Rhesus macaque BCMA are homologus.

Product Specifications

Background

Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) is also known as B-cell maturation protein (BCMA), CD antigen CD269, which is a member of the TNF-receptor superfamily. TNFRSF17 contains one TNFR-Cys repeat. TNFRSF17 is expressed in mature B-cells, but not in T-cells or monocytes. TNFRSF17 is receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. TNFRSF17 promotes B-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 can activate NF-kappa-B and JNK.

Specifications

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 32.1 kDa. The protein migrates as 35-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Accession Number

A0A2K5UD97-1

Expression Region

Met 1 - Ala 53

Host

HEK293

Target

BCMA

Conjugation

Unconjugated

Tag

C-Fc

Source

Cynomolgus / Rhesus macaque

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin

1.0 EU per μg

Purity

90%

Bioactivity

Immobilized Human BAFF, His Tag at 5 μg/mL (100 μL/well) can bind Cynomolgus / Rhesus macaque BCMA, Fc Tag (Cat. No. BCA-C5253) with a linear range of 0.05-2 ng/mL (QC tested).