Biotinylated Human Nectin-2 / CD112 Protein, Fc, Avitag™ (MALS verified)

Poliovirus receptor-related 2 (PVRL2) is also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), which is a human plasma membrane glycoprotein. PVRL2 is one of the plasma membrane components of adherens junctions. PVRL2 also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in PVRL2 gene have been associated with differences in the severity of multiple sclerosis. Also, PVRL2 binds with low affinity to TIGIT. Furthermore, PVRL2 acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV) .

Product Specifications

Background

Specifications

This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (Avitag™) . The protein has a calculated MW of 64.0 kDa. The protein migrates as 66 kDa under reducing (R) condition, and 130 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.

Accession Number

Q92692-2

Expression Region

Gln 32 - Leu 360

Host

HEK293

Target

Nectin-2

Conjugation

Biotin-labeled

Tag

C-Fc & C-Avi

Source

Human

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin

1.0 EU per μg

Purity

95%

Bioactivity

Immobilized Human PVRIG, Mouse IgG2a Fc Tag, low endotoxin at 2 μg/mL (100 μL/well) can bind Biotinylated Human Nectin-2, Fc,Avitag (Cat. No. CD2-H82F8) with a linear range of 0.2-13 ng/mL (QC tested).

Format

Powder

Buffer

Tris with Glycine, Arginine and NaCl, pH7.5

Additives

Trehalose

Molecular Weight

64.0 kDa

Additionnal Information

Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments

Shipping Conditions

Storage Conditions

-20°C

Package Size

25ug*1

Host or Source

HEK293

Species

Human

Protein ID

Q92692-2

Preservative

Trehalose

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

NBP2-68975-25ul 25 µL

Rabbit Polyclonal KA2/GRIK5/Glutamate Receptor KA2 Antibody

Ask

View Details

MBS7207873-01 48 Well

Goat CKLF-like MARVEL transmembrane domain-containing protein 5 (CMTM5) ELISA Kit

Ask

View Details

MBS7207873-02 96 Well

Goat CKLF-like MARVEL transmembrane domain-containing protein 5 (CMTM5) ELISA Kit

Ask

View Details

MBS7207873-03 5x 96 Well

Goat CKLF-like MARVEL transmembrane domain-containing protein 5 (CMTM5) ELISA Kit

Ask

View Details

MBS7207873-04 10x 96 Well

Goat CKLF-like MARVEL transmembrane domain-containing protein 5 (CMTM5) ELISA Kit

Ask

View Details

CB548349 1 Block

Frozen Tissue Blocks, Breast

Ask

View Details