Human uPAR / PLAUR Protein, His Tag (MALS verified)
Human uPAR, His Tag (UPR-H5226) is expressed from human 293 cells (HEK293) . It contains AA Leu 23 - Arg 303 (Accession # AAH02788) .
Product Specifications
Background
Urokinase plasminogen activator surface receptor (U-PAR) is also known as PLAUR, Monocyte activation antigen Mo3, CD antigen CD87. PLAUR contains three UPAR/Ly6 domains. U-PAR is expressed in neurons of the rolandic area of the brain (at protein level) and is also expressed in the brain. PLAUR / CD87 interacts with MRC2, SRPX2 and SORL1. PLAUR / UPAR acts as a receptor for urokinase plasminogen activator and plays a role in localizing and promoting plasmin formation. U-PAR mediates the proteolysis-independent signal transduction activation effects of U-PA.
Specifications
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 32.3 kDa. The protein migrates as 40-55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Accession Number
AAH02788
Expression Region
Leu 23 - Arg 303
Host
HEK293
Target
UPAR
Conjugation
Unconjugated
Tag
C-7xHis
Source
Human
Stability
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Endotoxin
1.0 EU per μg
Purity
92%
Bioactivity
Measured by its inhibitory ability in a competitive ELISA.
Serial dilutions of Human uPAR, His Tag (Cat. No. UPR-H5226) were added into Human PLAU, His Tag (Cat. No. PLU-H5229) : Biotinylated Human uPAR, His,Avitag (Cat. No. UPR-H82E7) binding reactions. The half maximal inhibitory concentration (IC50) is 2.96 μg/mL (QC tested).
Format
Powder
Buffer
PBS, pH7.4
Additives
Trehalose
Molecular Weight
32.3 kDa
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
500ug*2
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/UPR-H5226.pdf
Species
Human
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