Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Human SMAC / Diablo Protein, His Tag

Diablo homolog, mitochondrial (DIABLO) is also known as direct IAP-binding protein with low pI and second mitochondria-derived activator of caspase (SMAC), which can interact with BIRC2/c-IAP1, BIRC3/c-IAP2, XIAP/BIRC4, BIRC6/bruce and BIRC7/livin. Acting by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP), DIABLO can also promote apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Also, DIABLO inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Furthermore, DIABLO is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.

Product Specifications

Background

Diablo homolog, mitochondrial (DIABLO) is also known as direct IAP-binding protein with low pI and second mitochondria-derived activator of caspase (SMAC), which can interact with BIRC2/c-IAP1, BIRC3/c-IAP2, XIAP/BIRC4, BIRC6/bruce and BIRC7/livin. Acting by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP), DIABLO can also promote apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Also, DIABLO inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Furthermore, DIABLO is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.

Specifications

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 21.7 kDa. The protein migrates as 22 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) .

Accession Number

NP_063940

Expression Region

Ala 56 - Asp 239

Host

E. coli

Target

SMAC

Conjugation

Unconjugated

Tag

C-6xHis

Source

Human

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin

1.0 EU per μg

Purity

95%

Format

Powder

Buffer

20 mM HEPES, 150 mM NaCl, pH7.5

Additives

Trehalose

Molecular Weight

21.7 kDa

Additionnal Information

Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments

Shipping Conditions

RT

Storage Conditions

-20°C

Package Size

500ug*2

Host or Source

E. coli

Species

Human

Protein ID

NP_063940

Preservative

Trehalose

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Mouse Monoclonal GPR15 Antibody (367902) [CoraFluor 1]

FAB3654CL1 0.1 mL

Mouse Monoclonal GPR15 Antibody (367902) [CoraFluor 1]

Ask

Ryr2-set siRNA/shRNA/RNAi Lentivector (Mouse)

42921094 4x 500 ng

Ryr2-set siRNA/shRNA/RNAi Lentivector (Mouse)

Ask

pExpress-1-Cstf3 Plasmid

PVT41611 2 µg

pExpress-1-Cstf3 Plasmid

Ask

HHIP Knockout HAP1 Polyclonal Cells

ARG22513 1 Million

HHIP Knockout HAP1 Polyclonal Cells

Ask

MGAT1 Overexpression Lysate (Native) - (Dry Ice)

NBP2-09399 0.1 mg

MGAT1 Overexpression Lysate (Native) - (Dry Ice)

Ask

RAB38 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)

38329111 3x 1.0 µg

RAB38 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)

Ask