Human APP / SAPPbeta Protein, His Tag (MALS verified)
Human SAPPbeta, His Tag (APP-H52H5) is expressed from human 293 cells (HEK293) . It contains AA Leu 18 - Met 652 (Accession # P05067-8) .
Product Specifications
Background
Amyloid precursor protein (APP) is a type I integral membrane protein ubiquitously expressed in many tissues and concentrated in the synapses of neurons. It has three predominant splice variants: APP695, APP751, and APP770. The majority of APP is cleaved at the plasma membrane by the α-secretase in the non-amyloidogenic pathway. The amyloidogenic pathway starts with β-secretase cleavage by BACE1 on the N-terminal part of the Aβ domain, releasing sAPPβ from a membrane-anchored fragment named βCTF or C99, which is subsequently cleaved by γ-secretase to release Aβ.
Specifications
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 73.8 kDa. The protein migrates as 100-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Accession Number
P05067-8
Expression Region
Leu 18 - Met 652
Host
HEK293
Target
APP
Conjugation
Unconjugated
Tag
C-10xHis
Source
Human
Stability
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Endotoxin
1.0 EU per μg
Purity
95%
Format
Powder
Buffer
PBS, 0.3 M Arginine, pH7.4
Additives
Trehalose
Molecular Weight
73.8 kDa
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
100ug*1
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/APP-H52H5.pdf
Species
Human
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