Human FKBP12 / FKBP1A Protein, His Tag
Peptidyl-prolyl cis-trans isomerase FKBP1A, a member of the FKBP-type PPIase family and FKBP1 subfamily, is also known as FK506-binding protein 1A, immunophilin FKBP12 and 12 kDa FK506-binding protein, which contains one PPIase FKBP-type domain. FKBP1A is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 (tacrolimus) and rapamycin (sirolimus) .FKBP1A interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. FKBP1A can also interact with multiple intracellular calcium release channels including the tetrameric skeletal muscle ryanodine receptor. Furthermore, FKBP1A can recruite SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal.
Product Specifications
Background
Specifications
Accession Number
P62942-1
Expression Region
Met 1 - Glu 108
Host
E. coli
Target
FKBP12
Conjugation
Unconjugated
Tag
C-6xHis
Source
Human
Stability
Endotoxin
1.0 EU per μg
Purity
95%
Format
Powder
Buffer
50 mM HEPES, 150 mM NaCl, pH7.5
Additives
Trehalose
Molecular Weight
12.8 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
250ug*4
Host or Source
E. coli
Species
Human
Protein ID
P62942-1
Preservative
Trehalose
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