Human ACHE / Acetylcholinesterase Protein, His Tag (active enzyme)
Human ACHE, His Tag (AHE-H52H3) is expressed from human 293 cells (HEK293) . It contains AA Glu 32 - Leu 614 (Accession # P22303-1) .
Product Specifications
Background
The enzyme acetylcholinesterase, also known as AChE or acetylhydrolase, is the primary cholinesterase in the body. It is a serine hydrolase whose primary function is to catalyzes the breakdown of acetylcholine (ACh) and of some other choline esters that function as neurotransmitters. AChE is found at mainly neuromuscular junctions and in chemical synapses of the cholinergic type, where its activity serves to terminate synaptic transmission. Acetylcholine deficit has been found in Alzheimer's disease (AD) ans is associated with cognetive decline. Therefore, AChE has been reported to be a viable therapeutic target for the treatment of AD and other dementias. To this end, acetylcholinesterase inhibitors (AChEIs) are commonly used.
Specifications
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 66.5 kDa. The protein migrates as 65-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Accession Number
P22303-1
Expression Region
Glu 32 - Leu 614
Host
HEK293
Target
ACHE
Conjugation
Unconjugated
Tag
C-10xHis
Source
Human
Stability
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Endotoxin
1.0 EU per μg
Purity
95%
Format
Powder
Buffer
PBS, pH7.4
Additives
Trehalose
Molecular Weight
66.5 kDa
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
20ug*1
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/AHE-H52H3.pdf
Species
Human
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