Human Neuropilin-1 / NRP1 / CD304 Protein, Mouse IgG2a Fc Tag (MALS verified)

Neuropilin-1 (NRP1) is also known as Vascular endothelial cell growth factor 165 receptor (VEGF165R), CD antigen CD304, which belongs to the neuropilin family. The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells.

This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 96.7 kDa. The protein migrates as 110-130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Immobilized Human VEGF165, His Tag (Cat. No. VE5-H5248) at 2 μg/mL (100 μL/well) can bind Human Neuropilin-1, Mouse IgG2a Fc Tag (Cat. No. NR1-H5253) with a linear range of 0.2-5 ng/mL (QC tested).