Alexa Fluor™ 555-Labeled Human GUCY2C / Guanylyl cyclase C Protein, His TagStar Staining

Alexa Fluor 555-Labeled Human GUCY2C Protein, His Tag (GUC-HA2H6) is produced via conjugation of AF555 to Human GUCY2C Protein, His Tag with a new generation site-specific technology under Star Staining labeling platform. Human GUCY2C Protein, His Tag is expressed from human 293 cells (HEK293) . It contains AA Ser 24 - Gln 430 (Accession # P25092-1) .

Product Specifications

Background

GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.

Specifications

This protein carries a polyhistidine tag at the C-terminus.

Accession Number

P25092-1

Expression Region

Ser 24 - Gln 430

Host

HEK293

Target

GUCY2C

Conjugation

AF555 Labeled

Tag

C-10xHis

Source

Human

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.