Human CD45 / PTPRC Protein, Llama IgG2b Fc Tag, low endotoxin
Human CD45 Protein, Llama IgG2b Fc Tag (CD5-H5259) is expressed from human 293 cells (HEK293) . It contains AA Gln 26 - Lys 577 (Accession # P08575-3) .
Product Specifications
Background
CD45 is a receptor protein tyrosine phosphatase, also known as Ly-5 or leukocyte common antigen. CD45 mainly involves in the initiation of T cell receptor signaling by controlling the activation of the Src family protein-tyrosine kinases Lck and Fyn. CD45 deficiency causes in T- and B-lymphocyte dysfunction in the form of severe combined immune deficiency. It also takes a significant role in autoimmune diseases and cancer as well as in infectious diseases including fungal infections.
Specifications
This protein carries a llama IgG2b Fc tag at the C-terminus. The protein has a calculated MW of 88.6 kDa. The protein migrates as 200-250 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Accession Number
P08575-3
Expression Region
Gln 26 - Lys 577
Host
HEK293
Target
CD45
Conjugation
Unconjugated
Tag
C-LlamaFc (LlamaIgG2b)
Source
Human
Stability
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Endotoxin
0.05 EU per μg
Purity
90%
Format
Powder
Buffer
50 mM Tris, 200 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
Additives
Trehalose
Molecular Weight
88.6 kDa
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
100ug*1
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/CD5-H5259.pdf
Species
Human
Curated Selection
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