PE-Labeled Human Siglec-10 Protein, His Tag (recommended for neutralizing assay) (Site-specific conjugation)

The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.

Flow Cytometry (Neutralizing assay), Please note that this product is NOT compatible to streptavidin detection system. Designed and validated to use together with CD24 overexpressing HEK293 cells. Not suitable to use together with overexpressing CHO cells for high non-specific background from proteins of high sialylation. Not recommended and validated to use together with tumor cells.