Carboxypeptidase G2 (CPG2) Inhibitor
Product Specifications
UNSPSC Description
Carboxypeptidase G2 (CPG2) Inhibitor is a novel Carboxypeptidase G2 (CPG2) Inhibitor, Antitumor agents.
Target Antigen
Carboxypeptidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/carboxypeptidase-g2-_cpg2_-inhibitor.html
Purity
98.03
Solubility
10 mM in DMSO|H2O : 1.43 mg/mL (ultrasonic)
Smiles
O=C(SC(C=C1)=CC=C1OC)N[C@@H](CCC(O)=O)C(O)=O
Molecular Weight
313.33
References & Citations
[1]Khan, Tariq H.; Eno-Amooquaye, Ebun A.; Searle, Frances et al. Novel Inhibitors of Carboxypeptidase G2 (CPG2): Potential Use in Antibody-Directed Enzyme Prodrug Therapy. Journal of Medicinal Chemistry (1999), 42(6), 951-956.|[2]Friedlos F, Lehouritis P, Ogilvie L et al. Attenuated Salmonella targets prodrug activating enzyme carboxypeptidase G2 to mouse melanoma and human breast and colon carcinomas for effective suicide gene therapy. Clin Cancer Res. 2008 Jul 1;14(13):4259-66.|[3]Schepelmann S, Ogilvie LM, Hedley D et al. Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2. Cancer Res. 2007 May 15;67(10):4949-55.|[4]Schepelmann S, Hallenbeck P, Ogilvie LM et al. Systemic gene-directed enzyme prodrug therapy of hepatocellular carcinoma using a targeted adenovirus armed with carboxypeptidase G2. Cancer Res. 2005 Jun 15;65(12):5003-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-70003/Carboxypeptidase-G2-CPG2-Inhibitor-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-70003/Carboxypeptidase-G2-CPG2-Inhibitor-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
192203-60-4
Available Sizes
Curated Selection
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