Carboxypeptidase G2 (CPG2) Inhibitor

Carboxypeptidase G2 (CPG2) Inhibitor is a novel CPG2 inhibitor with an Ki of 0.3 μM. Carboxypeptidase G2 (CPG2) Inhibitor effectively neutralizes the CPG2 activity in non-tumor sites, allowing for earlier administration of the drug and forming a complementary strategy with antibody clearance strategies. Carboxypeptidase G2 (CPG2) Inhibitor can be used for the study of antibody-directed enzyme prodrug therapy (ADEPT) [1].

Product Specifications

CAS Number

[192203-60-4]

Product Name Alternative

CPG2 Inhibitor

UNSPSC

12352005

Target

Carboxypeptidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/carboxypeptidase-g2-_cpg2_-inhibitor.html

Purity

98.03

Solubility

10 mM in DMSO|H2O : 1.43 mg/mL (ultrasonic)

Smiles

O=C(SC(C=C1)=CC=C1OC)N[C@@H](CCC(O)=O)C(O)=O

Molecular Formula

C13H15NO6S

Molecular Weight

313.33

References & Citations

[1]Khan, Tariq H.; Eno-Amooquaye, Ebun A.; Searle, Frances et al. Novel Inhibitors of Carboxypeptidase G2 (CPG2) : Potential Use in Antibody-Directed Enzyme Prodrug Therapy. Journal of Medicinal Chemistry (1999), 42 (6), 951-956.