(R) -Carvedilol

(R) -Carvedilol ((R) -BM 14190) is the orally active R-isomer of Carvedilol (HY-B0006) . (R) -Carvedilol has α-receptor blocking activity but no β-receptor blocking activity. (R) -Carvedilol inhibits spontaneous Ca2+ waves. (R) -Carvedilol inhibits stress-induced ventricular tachycardia and delays the development of UV-induced skin tumors and reduces their malignancy[1][2][3].

Product Specifications

CAS Number

[95093-99-5]

Product Name Alternative

(R) -BM 14190

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adrenergic Receptor; Calcium Channel

Type

Reference compound

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/r-carvedilol.html

Purity

99.94

Solubility

DMSO : 220 mg/mL (ultrasonic)

Smiles

O[C@H](CNCCOC1=CC=CC=C1OC)COC2=CC=CC(N3)=C2C4=C3C=CC=C4

Molecular Formula

C24H26N2O4

Molecular Weight

406.47

Precautions

H302, H315, H319, H335

References & Citations

[1]Wu T, et al. Protective effects of S-carvedilol on doxorubicin-induced damages to human umbilical vein endothelial cells and rats. J Appl Toxicol. 2019 Aug;39 (8) :1233-1244.|[2]Zhang J, et al. Non-β-blocking R-carvedilol enantiomer suppresses Ca2+ waves and stress-induced ventricular tachyarrhythmia without lowering heart rate or blood pressure. Biochem J. 2015 Sep 1;470 (2) :233-42. |[3]Sardar PK, et al. Oral delivery of the non-β-blocking R-carvedilol enantiomer for skin cancer chemoprevention in SKH-1 mice. AAPS Open. 2025;11:1.