Thiolutin
Product Specifications
UNSPSC Description
Thiolutin (Acetopyrrothin) is a disulfide-containing antibiotic and anti-angiogenic compound produced by Streptomyces. Thiolutin inhibits the JAMM metalloproteases Csn5, Associated-molecule-with-the-SH3-Domain-of-STAM (AMSH) and Brcc36[1]. Thiolutin is a potent and selective inhibitor of endothelial cell adhesion accompanied by rapid induction of Heat-shock protein beta-1 (Hsp27) phosphorylation[2].
Target Antigen
Antibiotic; Bacterial; Deubiquitinase; Endogenous Metabolite
Type
Natural Products
Related Pathways
Anti-infection;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/thiolutin.html
Purity
99.24
Solubility
DMSO : 6.25 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
CC(NC1=C2C(N(C)C1=O)=CSS2)=O
Molecular Weight
228.29
References & Citations
[1]Lauinger L, et al. Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases. Nat Chem Biol. 2017 Jul;13(7):709-714.|[2]Jia Y, et al. Thiolutin inhibits endothelial cell adhesion by perturbing Hsp27 interactions with components of the actin and intermediate filament cytoskeleton. Cell Stress Chaperones. 2010 Mar;15(2):165-81.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N6712/Thiolutin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N6712/Thiolutin-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
87-11-6
Available Sizes
Curated Selection
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