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Human TrkC / NTRK3 Protein, Fc Tag (MALS verified)

Tropomyosin receptor kinase C (TrkC), also known as NT-3 growth factor receptor, neurotrophic tyrosine kinase receptor type 3, or TrkC tyrosine kinase is a protein that in humans is encoded by the NTRK3 gene. It belongs to the tropomyosin-related kinase (Trk) family of receptor tyrosine kinases (TrkA, TrkB, and TrkC) . TrkC is the high affinity catalytic receptor for the neurotrophin NT-3 (neurotrophin-3) . As such, TrkC mediates the multiple effects of this neurotrophic factor, which includes neuronal differentiation and survival.

Product Specifications

Background

Tropomyosin receptor kinase C (TrkC), also known as NT-3 growth factor receptor, neurotrophic tyrosine kinase receptor type 3, or TrkC tyrosine kinase is a protein that in humans is encoded by the NTRK3 gene. It belongs to the tropomyosin-related kinase (Trk) family of receptor tyrosine kinases (TrkA, TrkB, and TrkC) . TrkC is the high affinity catalytic receptor for the neurotrophin NT-3 (neurotrophin-3) . As such, TrkC mediates the multiple effects of this neurotrophic factor, which includes neuronal differentiation and survival.

Specifications

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 71.2 kDa. The protein migrates as 95-130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Accession Number

Q16288-1

Expression Region

Cys 32 - Thr 429

Host

HEK293

Target

TrkC

Conjugation

Unconjugated

Tag

C-Fc

Source

Human

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin

1.0 EU per μg

Purity

95%

Bioactivity

Immobilized Human NT-3 / Neurotrophin-3 Protein at 2 μg/mL (100 μL/well) can bind Human TrkC Protein, Fc Tag (Cat. No. TRC-H5256) with a linear range of 0.3-5 ng/mL (QC tested).

Format

Powder

Buffer

PBS, pH7.4

Additives

Trehalose

Molecular Weight

71.2 kDa

Additionnal Information

Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments

Shipping Conditions

RT

Storage Conditions

-20°C

Package Size

500ug*2

Host or Source

HEK293

Species

Human

Protein ID

Q16288-1

Preservative

Trehalose

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