FKBP51-Hsp90-IN-1
FKBP51-Hsp90-IN-1 (Compound D10) is a selective inhibitor of the FKBP51-Hsp90 protein-protein interaction, with an IC50 value of 0.1 μM against FKBP51. FKBP51-Hsp90-IN-1 can be used in the research of stress-related diseases, Alzheimer's disease, and metabolic disorders[1].
Product Specifications
CAS Number
433313-64-5
UNSPSC
12352005
Target
FKBP; HSP
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/fkbp51-hsp90-in-1.html
Solubility
10 mM in DMSO
Smiles
CC1=C(C(C(N)=O)=C(S1)NC(CCCC(NC2=C(C(C)=C(S2)C)C(N)=O)=O)=O)C
Molecular Formula
C19H24N4O4S2
Molecular Weight
436.55
References & Citations
[1]Wang L, et al. Structure-based discovery of small molecule inhibitors of FKBP51-Hsp90 protein-protein interaction. Eur J Med Chem. 2024;270:116356.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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