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Anti-Bcl-3 Antibody

Hamster Monoclonal Antibody specific to Bcl-3

Product Specifications

Product Name Alternative

BCL-3, Proto-oncogene BCL3

Gene Name

BCL3

Gene ID

602

NCBI Gene ID

<a href="https://www.ncbi.nlm.nih.gov/gene/?term=BCL3">BCL3</a>

UniProt

P20749

Accession Number

NP_005169

Cellular Locus

Nucleus. Cytoplasm, Cytoplasm, perinuclear region

Host

Hamster

Reactivity

Human, Mouse

Immunogen

Recombinant mouse Bcl-3- 6His.

Target Antigen

B-cell lymphoma 3 protein

Target

Bcl-3

Clonality

Monoclonal

Isotype

IgG1

Type

Antibody

Applications

WB, ELISA

Field of Research

Apoptosis

Purification Method

Purified by Protein G affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium which is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity). {PubMed:8453667}.

Additionnal Information

Immunoblotting: use at 2ug/ml. A band of approx. 64kDa is detected <br><br>ELISA: <br><br>End user should determine optimal concentration for each sample. <br><br>Positive control: Jurkat T cell lysate.See Bassetti MFJ et al. 2009 International Immunology 21: 339-348.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.

Product Datasheet

https://www.qedbio.com/wp-content/uploads/pdf/11067.pdf

Specificity

This antibody recognizes human and mouse Bcl-3.

Formulation

PBS, pH 7.4.

Buffer pH

pH 7.4

Target Background

The gene encoding Bcl-3 was first identified as the gene altered in some cases of chronic B cell lymphocytic leukemia and was later found to belong to the IkappaB subfamily of inhibitors of NFkappaB transcription factors. Bcl- 3 does not have DNA-binding activity, but it interacts with NFkappaB1 and NFkappaB2 which, when bound to DNA, repress gene transcription. Therefore, Bcl-3 may promote gene expression that is repressed by members of the NFkappaB family. Bcl-3 RNA is highly expressed in spleen and liver with lower levels of expression in heart, skeletal muscle, lung, kidney, and testes.

CAS Number

9007-83-4

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