8-Azaadenosine

8-Azaadenosine is a potent ADAR1 inhibitor and an A-to-I editing inhibitor. 8-Azaadenosine blocks RNA editing and inhibits proliferation, 3D growth, invasion, and migration in thyroid cancer cells[1][2].

Product Specifications

CAS Number

[10299-44-2]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Adenosine Deaminase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/8-azaadenosine.html

Concentration

10mM

Purity

99.94

Solubility

DMSO : 250 mg/mL (ultrasonic) |H2O : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

NC1=NC=NC2=C1N=NN2[C@@H]3O[C@@H]([C@H]([C@H]3O)O)CO

Molecular Formula

C9H12N6O4

Molecular Weight

268.23

Precautions

H315, H319, H335

References & Citations

[1]Maria Anna Zipeto, et al. ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis. Cell Stem Cell. 2016 Aug 4;19 (2) :177-191.|[2]Julia Ramírez-Moya, et al. ADAR1-mediated RNA editing is a novel oncogenic process in thyroid cancer and regulates miR-200 activity. Oncogene. 2020 Apr;39 (18) :3738-3753.