PND-1186 (hydrochloride)

PND-1186 hydrochloride (VS-4718 hydrochloride) is a potent, highly-specific and reversible inhibitor of FAK with an IC50 of 1.5 nM. PND-1186 hydrochloride selectively promotes tumor cell apoptosis[1].

Product Specifications

CAS Number

[1356154-94-3]

Product Name Alternative

VS-4718 (hydrochloride) ; SR-2516 (hydrochloride)

UNSPSC

12352005

Target

Apoptosis; FAK

Type

Reference compound

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pnd-1186-hydrochloride.html

Concentration

10mM

Purity

99.92

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 20 mg/mL (ultrasonic)

Smiles

[H]Cl.O=C(NC)C1=CC=CC=C1NC2=CC(NC3=CC=C(N4CCOCC4)C=C3OC)=NC=C2C(F)(F)F

Molecular Formula

C25H27ClF3N5O3

Molecular Weight

537.96

References & Citations

[1]Tanjoni I, et al. PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer Biol Ther. 2010 May 15;9 (10) :764-77.