Canniprene

Canniprene, an isoprenylated bibenzyl unique to Cannabis sativa, is a potent inhibitor of 5-lipoxygenase (5-LO) activity (IC50=0.4 μM) and cyclooxygenase/microsomal prostaglandin E2 synthase (PGE2; IC50=10 μM) . Canniprene inhibits the production of inflammatory eicosanoids and affects the generation of prostaglandins[1].

Product Specifications

CAS Number

[70677-47-3]

UNSPSC

12352005

Target

Lipoxygenase; Prostaglandin Receptor

Type

Natural Products

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/canniprene.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

OC1=C(OC)C=CC(CCC2=CC(OC)=CC(O)=C2)=C1C/C=C(C)\C

Molecular Formula

C21H26O4

Molecular Weight

342.43

References & Citations

[1]Allegrone G, et al. The Bibenzyl Canniprene Inhibits the Production of Pro-Inflammatory Eicosanoids and Selectively Accumulates in Some Cannabis sativa Strains. J Nat Prod. 2017 Mar 24;80 (3) :731-734.