L-Phenylalanine-13C9,15N
L-Phenylalanine-13C9,15N is the 13C- and 15N-labeled L-Phenylalanine. L-Phenylalanine ((S) -2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
Product Specifications
CAS Number
[878339-23-2]
Product Name Alternative
(S) -2-Amino-3-phenylpropionic acid-13C9,15N
UNSPSC
12352005
Hazard Statement
H332
Target
Calcium Channel; Endogenous Metabolite; iGluR
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/l-phenylalanine-13c9-15n.html
Purity
99.52
Solubility
H2O : 20.83 mg/mL (ultrasonic)
Smiles
O[13C]([13C@@H]([13CH2][13C]1=[13CH][13CH]=[13CH][13CH]=[13CH]1)[15NH2])=O
Molecular Formula
13C9H11 15NO2
Molecular Weight
175.12
Precautions
H332
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
NMDA Receptor
Available Sizes
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