Maraviroc (Standard)
Maraviroc (Standard) is the analytical standard of Maraviroc. This product is intended for research and analytical applications. Maraviroc (UK-427857) is a selective CCR5 antagonist with activity against human HIV.
Product Specifications
CAS Number
376348-65-1
Product Name Alternative
UK-427857 (Standard)
UNSPSC
12352005
Target
CCR; HIV; Reference Standards
Type
Reference compound
Related Pathways
Anti-infection; GPCR/G Protein; Immunology/Inflammation; Others
Field of Research
Inflammation/Immunology; Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/maraviroc-standard.html
Smiles
O=C(C1CCC(F)(F)CC1)N[C@H](C2=CC=CC=C2)CCN3[C@H]4C[C@@H](N5C(C)=NN=C5C(C)C)C[C@@H]3CC4
Molecular Formula
C29H41F2N5O
Molecular Weight
513.67
References & Citations
[1]Dorr P, et al. Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity. Antimicrob Agents Chemother. 2005 Nov;49 (11) :472|[2]Mencarelli A, et al. Highly specific blockade of CCR5 inhibits leukocyte trafficking and reduces mucosal inflammation in murine colitis. Sci Rep. 2016 Aug 5;6:30802.|[3]Romero-Sánchez MC, et al. Effect of maraviroc on HIV-disease progression-related biomarkers. Antimicrob Agents Chemother. 2012 Nov;56 (11) :5858-64.|[4]Huilin Mou, et al. NRSF and CCR5 Established Neuron-glia Communication during Acute and Chronic Stresses. Journal of Drug Metabolism & Toxicology. January 10, 2016.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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