Pluripotin

Pluripotin is a dual inhibitor of ERK1 and RasGAP with KDs of 98 nM and 212 nM, respectively. Pluripotin also inhibits RSK1, RSK2, RSK3, and RSK4 with IC50s of 0.5, 2.5, 3.3, and 10.0 μM, respectively.

Product Specifications

CAS Number

[839707-37-8]

Product Name Alternative

SC1

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

ERK; Ribosomal S6 Kinase (RSK)

Type

Reference compound

Related Pathways

MAPK/ERK Pathway; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Pluripotin.html

Purity

98.86

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

CN1C(NC2=NC=C3C(N(C)C(N(C4=CC(NC(C5=CC=CC(C(F)(F)F)=C5)=O)=CC=C4C)C3)=O)=N2)=CC(C)=N1

Molecular Formula

C27H25F3N8O2

Molecular Weight

550.54

Precautions

H315, H319, H320

References & Citations

[1]Chen S, et al. Self-renewal of embryonic stem cells by a small molecule. Proc Natl Acad Sci U S A. 2006 Nov 14;103 (46) :17266-71.|[2]Mertins SD, et al. A small molecule (pluripotin) as a tool for studying cancer stem cell biology: proof of concept. PLoS One. 2013;8 (2) :e57099.