6β-Hydroxy Eplerenone

6β-Hydroxy Eplerenone is a metabolite of Eplerenone (HY-B0251) . 6β-Hydroxy Eplerenone plays an important role in the research of hypertension, atherosclerosis, chronic systolic heart failure (HF) and cardiovascular (CV) [1].

Product Specifications

CAS Number

[209253-80-5]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/6β-hydroxy-eplerenone.html

Solubility

10 mM in DMSO

Smiles

C[C@@]12[C@]34[C@]([C@@H]([C@H](C1=CC(CC2)=O)O)C(OC)=O)([H])[C@@]5([H])[C@](C[C@@]3([H])O4)([C@]6(CCC(O6)=O)CC5)C

Molecular Formula

C24H30O7

Molecular Weight

430.49

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Chyung S Cook, et al. Involvement of CYP3A in the metabolism of eplerenone in humans and dogs: differential metabolism by CYP3A4 and CYP3A5. Drug Metab Dispos. 2002 Dec;30 (12) :1344-51.